Intractable or Treatment Resistant Depression (TRD)

What is it?

Intractable means goes on for a long time. Intractable or Treatment Resistant Depression or TRD is therefore usually defined as non-response to attempts at treating depression with an adequate dose for an adequate time of two or more anti-depressants, and following a complete psychiatric assessment.


Not all anti-depressants are as effective as others, and they each suit different individuals. No anti-depressant treatment works in everyone and it is common for each individual patient to experience and tolerate the side effects in different ways.  Almost two thirds of patients still experience ongoing incapacitating symptoms after their initial treatment, and for some it takes much trial and error to find a treatment which works. For other patients, initially successful treatment may fade in benefit with time leading to a recurrence of their symptoms.  


The management of TRD therefore requires a careful and detailed assessment, including the severity of your symptoms, ruling out any other possible causes of the depressive symptoms you may have. Careful consideration will also be given to alternative anti-depressants you could try and in what order, which are then carefully tailored to your needs by balancing benefit against tolerability. The place of talking therapies such as Cognitive Behavioural Therapy (CBT) will also be discussed with you as part of an agreed treatment plan which may also include newer drugs, drug combinations or other additional therapies. The crucial factor is usually the selection of a treatment with minimal intolerable side effects, and which is done as quickly as possible, not only to relieve suffering, but also to prevent further worsening.

It is our belief that almost every person with depression can be helped eventually and hence no one should ever be dismissed as untreatable.

We use cookies, just to track visits to our website, we store no personal details. ACCEPT COOKIES What are cookies?